The StarTimes Uganda Premier League reigning champions capitalised on the home-ground advantage to defeat Busoga United 3-0.
Ceaser Manzoki scored twice while Ibrahim Orit scored the other one as The Venoms eased past Busoga at St. Mary’s Stadium Kitende.
Disan Galiwango’s cross was met by Orit and the forward headed it in the 32nd minute to put Vipers in the driving seat.
Manzoki made it 2-0 a minute after the break when he connected Galiwango’s cross.
The third goal came with two minutes to full time when the Congolese, once again, hit the back of the net when he converted a Dan Sserunkuma cross.
Elsewhere, SC Villa kicked off their Uganda Cup campaign with a first leg 1-0 loss to Ndejje University at Bombo Barracks Stadium on Monday.
Brian Ssali scored the lone goal to give the minnows a slim advantage ahead of the second leg.
The visitors came into the match as favourites owing to their experience in the competition as well as the Ugandan Premier League.
However, they failed to get their way past the Fufa Big League side who played with composure and belief.
They were cautious in approach and ensured the ball was cleared from dangerous areas.
Meanwhile, BUL FC claimed a 2-0 win away to Black Power FC.
The Jinja-based side had to wait until the 19th minute to score their first goal courtesy of Simon Peter Oketch.
Deogracious Ojok scored the second goal for the visitors in the 27th minute to ensure they carried a huge advantage ahead of the second meeting in the annual competition.
Wakiso Giants also defeated Water 2-1 on Monday evening.
Water were the first to score courtesy of William Kiibi.
In the stroke of half-time, Wakiso levelled through Tom Masiko from the penalty spot before he completed his brace 10 minutes after the restart.
Monday Uganda Cup results:
- SC Villa 0-How1 Ndejje University
Onduparaka FC 0-0 Luwero United
Terrazzo Tiles 1-1 Maroons
Vipers SC 3-0 Busoga United
Water 1-2 Wakiso Giants
Police 5-0 Calvary